Application of the thermofluor PaSTRy technique for improving foot-and-mouth disease virus vaccine formulation

Application of the thermofluor PaSTRy technique for improving foot-and-mouth disease virus vaccine formulation

Foot-and-mouth disease (FMD) has a major economic impact throughout the world and is a considerable threat to food security. Current FMD virus (FMDV) vaccines are made from chemically inactivated virus and need to contain intact viral capsids to maximize efficacy. FMDV exists as seven serotypes, each made up by a number of constantly evolving subtypes. A lack of immunological cross-reactivity b...

Lyophilizing Foot-and Mouth Disease Virus at Low Drying Temperature

Freeze-drying of foot and mouth disease virus and its application in inactivated virus vaccine production

Five different subtypes of foot and mouth disease (FMD) virus propagated in BHK21 C13 monolayer cell cultures, namely 05, A5/!0, A22, C¡ and Asia 1/1, were used to study the stability of live virus during freeze-drying and subsequent storage. Binary ethyleneimine-inactivated FMD virus vaccines adjuvanted with purified saponin, "Quil-A", without aluminium hydroxide gel, were examined before and ...

MODIFIED LIVt VIRUS VACCINE AGAINST FOOT - AND - MOUTH DISEASE

The situation of foot and mouth disease virus types and subtypes in Iran in 1980-1983